PhD Candidate and research assistant
Texas Tech University Health Sciences Center
Greetings! I'm delighted to connect with you on LinkedIn. As a dedicated Ph.D. candidate in Pharmaceutical Sciences, my work revolves around the fascinating realm of potential central nervous system candidate drugs and their interaction with the blood-brain barrier (BBB).
In my current project, I conduct comprehensive in vitro and in vivo analyses to decipher the transport mechanisms of molecules across the BBB. Specifically, I am investigating the intricate interactions between these molecules and the transporters (influx and efflux) present at the BBB. Additionally, I am estimating brain pharmacokinetic parameters in stroke conditions, shedding light on drug delivery efficacy.
To ensure accurate quantification of small molecules in various biological matrices, such as buffers, cells, plasma, and brain tissues, I employ a robust LCMS/MS method. This method has been meticulously developed and validated by the rigorous guidelines set by the US-FDA.
Furthermore, I am implementing an in-vivo brain ischemic stroke model (tMCAO) surgery, allowing me to investigate the brain uptake of different drugs under ischemic conditions. This approach promises valuable insights into potential treatments for stroke-related complications.
To predict brain pharmacokinetic parameters, I employ industry-standard software called WinNonlin. This modeling technique enables me to forecast crucial pharmacokinetic properties, assessing drug efficacy and optimization.
I take great pride in my research contributions, having published three reviews and five papers in highly regarded peer-reviewed journals. These publications, where I served as both first author and co-author, have impacted the scientific community and have been well-received due to their high quality and relevance.
I am excited to connect with fellow professionals in the field, exchange knowledge, and explore potential collaborations that can advance our collective understanding of central nervous system drug delivery and its implications for neurological disorders. Feel free to reach out if you'd like to discuss shared interests or explore opportunities for collaboration.