Postdoctoral Fellow University of Toronto, Toronto, Canada Toronto, Ontario, Canada
Although the conventional dermatopharmacokinetic (DPK) approach involving tape stripping is a relatively non-invasive method to understand the bioavailability and bioequivalence (BE) of topical dermatological products, it is usually tedious and can be time-consuming. It also entails numerous calculations and assumptions related to the estimation of parameters characterizing “absorption” into the skin, which may not accurately reflect the rate and extent of input into the skin. Therefore, we propose a novel model-based approach involving physiologically based DPK model for the direct estimation of drug “delivery” into the skin by obviating the need for numerous measurements and assumptions. In addition, it circumvents the need for gravimetric analysis of tapes as well as transepidermal water loss (TEWL) readings, making the procedure less tedious. A DPK model was developed to characterize drug “delivery” metrics into the skin to assess BE of a topical dermatological product.
Learning Objectives:
Conduct a dermatopharmacokinetic approach involving tape stripping methodology
Understand the steps involved in model-based dermatopharmacokinetic analysis
Utilize appropriate metrics to assess bioequivalence of topical dermatological products