Associate Professor St. John's University Jamaica, New York
Three-dimensional (3D) cell culture models are attracting significant attention by the researchers especially in cancer therapy as two-dimensional models have failed to replicate the 3D complexity of an in-vivo tumor. Due to their ability to mimic in vivo tissue environments, tumor architecture, 3D cell culture models are offering a prevailing tool in cancer research. Hence, 3D cell culture models are enabling safety assessment and efficient in-vitro drug screening to predict in vivo efficacy. Different 3D cell culture models available including spheroids, polymer/hydrogel scaffolds, hanging drop approach, bioreactors, organ-on-chips and 3D bio-printing structures are highlighted in this presentation. Choice of a suitable model depends on the type of application due to characteristic differences in complexity and functionality among different models. This will be a case-study driven presentation, where presentation will elaborate about the importance, origin and utility of such models. In addition, presenter will also use the examples from their own work, and also from the literature to validate the hypothesis about effectiveness of such approaches in drug discovery domain in coming years. Audience will be engaged with interactive presentation, Q/A session, and state-of-the art information being disseminated in a concise fashion.
Learning Objectives:
Learn about the FDA Modernization Act 2.0
Explore the drug discovery approaches utilizing 3D cell culture
Demonstrate understanding of testing of nanotherapeutic delivery systems in 3D cell culture models