Professsor University of Connecticut Storrs, Connecticut
Real time assessment is critical for drug development, especially for complex systems such as long acting implants and nanoparticle-based products . The talk will provide case examples of 1) in vivo imaging of long acting implants to understand the dynamic changes of implant structure as correlated to drug release, and 2) imaging nanoparticle delivery to tumors and the heterogeneity of intratumoral deposition to indicate treatment outcome.
Long acting implants have been mainly studied through in vitro drug release and in vivo pharmacokinetics evaluations. However, the implant formation in vivo might be different from in vitro. The implant structure changes in vivo and their implications are challenging to assess non-desdructively. A tool that is able to evaluate implant structures and drug release in real time would be very informative. The talk will illustrate an novel CT imaging based assessment for in situ forming long acting implants.
Nanoparticle delivery to tumors has been largely studied. However, there are only limited number of nanomedicines. The heterogeneity of tumor delivery and variations between patients may lead to clinical trial failures. A CT imaging based platform will be presented to show case the value of understanding the tumor delivery situation for predicting treatment efficacy.
Learning Objectives:
Upon completion, participant will be able to understand how imaging tools could facilitate the assessment of long acting implants in vivo in real time.
Upon completion, participant will be able to understand how to assess the tumor delivery heterogeneity of nanoparticles and its implications.
Upon completion, participant will be able to understand the application of imaging in product development.