Formulation and Delivery
Talles Ernica, MD
Global Technical Developer
Roquette America Inc.
Lower Gwynedd Township, Pennsylvania
Description: In this presentation, we will explore the challenges that arise when increasing production speed or compression force in the tableting process, as capping may occur, affecting tablet hardness and potentially hindering industrial upscaling. We will examine the development of texturized mannitol powders, such as spray-dried mannitol, for direct compression. Mannitol is a preferred excipient for APIs with stability issues in final drug formulations, due to its high chemical stability and compatibility with most drugs. Our study aims to understand the relationship between mannitol structure and the observed capping phenomena, providing insights to overcome these challenges and improve the tableting process.