Preclinical and Translational Sciences
Philip Kuehl, PhD
Senior Scientist
Lovelace Biomedical Research Institute
Albuquerque, New Mexico
Description: Little is known about how CBD pharmacokinetics differ between routes of administration, and duration of pulmonary exposure. Lovelace Biomedical performed research in rats on the pharmacokinetics and toxicity of CBD and its major metabolites (6-OH-CBD, 7-OH-CBD, 7-COOH-CBD, and CBD-Glucuronide) after single and repeat dose oral and inhalation administration and found that CBD is more rapidly absorbed and present in higher concentrations following inhalation than ingestion. Plasma levels are also higher following repeated exposure compared to single dose. Metabolites are present in plasma at a much lower level than the parent compound and CBD and some of the metabolites are distributed to the brain. This presentation will discuss respective results in more detail as well as the methods used for the performed research and its relevance for human consumption and potential limitations. Further, we will discuss similar data available on other cannabinoids that are relevant for both the medical and recreational use market.