Discovery and Basic Research
Robert Thorne, PhD (he/him/his)
Denali Fellow & Adjunct Associate Professor
Denali Therapeutics & University of Minnesota
San Francisco, California
Steven Louie, MS (he/him/his)
Associate Director
Moderna
Cambridge, Massachusetts
This keynote talk will focus on novel proteins called transport vehicles, where binding to brain endothelial cell-enriched targets such as the human transferrin receptor or CD98 heavy chain has been engineered into the IgG Fc. Data will be presented to illustrate how these modular transport vehicle platforms may be used to deliver antibodies, enzymes, proteins, and oligonucleotides across the blood-brain barrier to elicit multiple therapeutic effects in preclinical and clinical studies.