Preclinical and Translational Sciences
Pankaj Desai, PhD (he/him/his)
Professor
University of Cincinnati
Cincinnati, Ohio
Nader Sanai, MD (he/him/his)
Director
Ivy Brain Tumor Center at Barrow Neurological Institute
Phoenix, Arizona
Tissue-based clinical trialing has become increasingly essential in brain tumor drug development. Phase 0 and window-of-opportunity trial designs enable pharmacokinetic- and pharmacodynamic-driven studies to shape early-phase drug development. Interrogating human brain tumor patient tissue in the setting of experimental therapy exposure allows investigators to humanize preclinical models and sidestep some of the challenges posed by animal modeling of brain tumors. This Speaker Spotlight will highlight the scientific strategies and systems innovations underpinning new tissue-based clinical trials in neuro-oncology.