PhD student
University College London, United Kingdom
Ms Yingchang Ma, PhD student, University College London (UCL)
Publications:
1. Yingchang Ma, Steve Brocchini*, Gareth Williams*. Journal of Controlled Release. doi.org/10.1016/j.jconrel.2023.07.059
2. Yingchang Ma, Yang Zhang, Yuanjuan Zhai, Zhenhua Zhu, Ying Pan, Dawei Qian, Shulan Su, Xinsheng Fan*, Jinao Duan*. Molecules. https://doi.org/10.3390/molecules22010007.
Education experience:
- PhD in Pharmaceutics (UCL, Anticipated Sep 2024)
- MSc in Pharmaceutics (UCL, 2017-2018) Distinction
- BSc in Traditional Chinese Pharmacy (Nanjing University of Chinese Medicine, 2013-2017) 2:1 degree
Work experience:
- Teaching assistant (UCL, Sep 2021-Now)
- Marketing Specialist (AstraZeneca Shanghai, Mar 2019-June 2020)
- Researcher (Aptuit UK, May 2018-Aug 2018)
Research experience:
- PhD project:
§ Developing an in-situ HA-Tyr hydrogel platform to prolong the release of EVs as well as maintain their stability.
1. Formulated HA-Tyr hydrogel with tunable mechanism strength and gelling time.
2. Prolonged the EV release from the hydrogel for over one week with enhanced stability.
§ Developing injectable HA-Tyr-cyclodextrin (CD) hydrogels to prolong intraocular drug release.
1. Sustained release of sunitinib for over 20 days in a zero-order release profile in vitro.
- MSc project:
§ Developing liposomal formulations for intraocular delivery.
1. Prepared pirfenidone-loaded liposomes by thin film hydration and probe sonication methods.
2. Sustained release of pirfenidone for 7 days in vitro.
- Undergraduate project:
§ The molecular mechanism of a Chinese medicine formula Kai-Xin-San (KXS) on anti-depression effect.
1. Screened 12 active ingredients in KXS by sodium glutamate-induced HT22 cell damage model to determine their neuroprotective effects.
2. Discovered the induction of neuronal differentiation effect of active ingredients on PC12 cells.
3. Revealed the action mechanism of KXS on anti-depression on synaptic protein regulation. Treated the hippocampal neuron primary cells
with KXS, and explored the differential expression profiles of synaptic proteins in brain tissues and neuronal primary culture both on mRNA
transcription and protein levels.