PI
Geneaty Therapeutics, Inc./ KAIMRC
A highly motivated scientist with a strong background in pharmaceutical formulation, development of nano-delivery systems, vaccine development. I have worked on the delivery of RNA- based therapies and other biological such as mAbs. I have published several research articles and co-invented promising technologies.
Technical Experience
• Pharmaceutical Formulation development and characterization:
-Polymeric nanoparticles, include PLGA
-Novel siRNA complexations
- Emulsions,
- Lipid-based nanoparticles include: LNP, SLN, and liposomes
• Chemical synthesis:
- Pro-drug development
- Polymer conjugation: previous experience includes PEG200-C18 conjugation.
- Expertise include NMR operation.
• Cell culture and biological assay:
- Cell culturing and freezing, cytoxicity MTT assay, cell uptake studies.
- PCR
- ELISA
-Western blot
- Fluorescent microscopy
• Characterization of pharmaceutical formulations:
- stability studies,
-DLS, , TEM
- HPLC
- Lyophilization
- Dialysis
- Ultrafilitration
- Ultracentrifugation.
• Experimental animals: Extensive experience in handling several strains of mice, human and murine tumor implantation in mice (including subcutaneous tumors), chronic inflammation and arthritic models such as CAIA, CIA and LPS-mouse models, intraperitoneal and subcutaneous injection, IVIS imaging, in addition to terminal blood collection, and several organ collection. Animal experience also includes conducting pharmacokinetics and biodistribution studies.
Management, consultation and administrative skills:
Other experience related assets include business administrative skills, excellent presentation skills and good communication skills. Ability to consult, lead and manage teams, and work remotely.