RESEARCH ASSOCIATE Florida A&M UniversityCollege Of Pharmacy & Pharmaceutical Sciences Tallahassee, Florida
The lack of effective curative treatments for diabetic neuropathy (DN) necessitates research into more effective therapies. Streptozotocin 55 mg/kg intraperitoneally (i.p.) was administrated to induce DN in male Sprague-Dawley (SD) rats, whereas 30 mM high glucose (HG), which simulated hyperglycemia, was employed to induce neurotoxicity in Schwann cells. Our results demonstrated that BC (β-caryophyllene) and CBD (cannabidiol) administration post diabetes induction reduced thermal and mechanical hyperalgesia normalized nerve blood flow. The western blotting, IHC, ICC and QPCR data showed that BC and CBD combination upregulated AMPK (p < 0.001), SIRT3 (p < 0.01), Nrf2 (p < 0.01) and TFAM (p < 0.01) expression in the dorsal root ganglia (DRG) and HG insulted Schwann cells. Further, up-regulation of PINK1 (p < 0.01), PARKIN (p < 0.001), LC3 (p < 0.001) was also observed. BC and CBD demonstrated neuroprotective potential in both in-vitro and in-vivo models through regulating the mitochondrial biogenesis and mitophagy pathway.
Learning Objectives:
To understand the crosstalk between mitochondrial dysfunction and mitophagy in DN and molecular mechanism of BC and CBD in HG induced neurotoxicity in schwann cells and STZ induced diabetic neuropathy.
to understand the role of BC and CBD in diabetic neuropathy
to understand the role of Sirtuins and Inflammasome in Diabetic neuropathy