While the potential for lipids in pharmaceutical formulation is enormous, most available excipients do not have the required mechanical properties and processability to take full advantage of this potential with modern manufacturing technologies such as extrusion- and filament-based 3D-printing. Successful application of lipids to such advanced technologies can empower the development of patient-centric and point-of-care manufacturing platforms, which have proven paramount for future healthcare. This talk introduces polyglycerol esters of fatty acids as the first lipid candidates with stable performance using the prior mentioned manufacturing platforms. The audience will be introduced on how to modify the material (lipid excipient) and the process (extrusion and 3D-printing), to fit one another, accomplishing a novel lipid-based 3D-printed dosage form. Early application data with a drug substance including tailoring the release profile, as well as the physical properties of filaments and 3D-printed forms will be presented.
Learning Objectives:
List the challenges faced by lipid excipients with advanced manufacturing technologies, and describe possible strategies to overcome these challenges.
Describe and apply a novel extrusion approach for the manufacturing of flexible and 3D-printable lipid-based filaments.
Describe and conduct uncommon approach for quantifying the flexibility of lipid-based filaments.
Understand the limitations in design of commercial 3D-printers for pharmaceutical applications, and discuss possible modifications strategies.