This presentation will discuss the formulation challenges of delivering high drug load small molecule to the lungs via tradition jet milling methods. It will particularly focus on use of biocompatible and biodegradable excipients, such as lipids and phospholipids, for the delivery of small molecules for the treatment of asthma via spray drying. It will explore the effect of the excipients on the solid-state, surface characteristics, and aerodynamic performance of the co-spray dried formulation. Advanced surface characterization techniques will be described in order to determine the surface enrichment of one of the components in co-spray dried systems. Finally, the importance of adding small amounts of lipid excipients during spray drying and its effects on surface morphology, composition, cohesion and aerosol performance of drugs will be discussed.
Learning Objectives:
Participant will be able to describe spray drying as a technique to enable deep lung delivery
Participant will be able to list key powder properties that impact aerosol performance of spray dried formulations
Participant will be able to list the underlying principles by which excipients modify surface properties of co-spray dried particle