professor University of Minnesota st paul, Minnesota
This presentation will discuss how the BBB is a critical component of limiting drug delivery to brain tumors. In spite of common lore, the BBB is intact in regions of all glioblastoma (GBM) and during resection various molecules can be measured that give insights into the condition of the BBB and how it may influence drug delivery.
Learning Objectives:
recognize factors that limit drug delivery to brain tumors
appreciate the use of typically used standard of care drugs during resection to characterize BBB in regions of tumor
see how to use radiographic information to help guide dosing of investigational compounds in phase1/0 trials
