Principal Research Scientist AbbVie South San Francisco, California
Recent advances in flow cytometry have significantly increased capabilities for deeper and more refined multiparameter single-cell analysis in clinical trials. The capacity to measure substantially more parameters simultaneously has led to new and improved ways to identify, enumerate, and characterize individual cell populations in a sample. In turn, this has provided unique opportunities to better discriminate cells of interest in clinical conditions and monitor disease progression, understand drug mechanism of action, inform on target engagement, and assess drug efficacy. With this increased complexity and sophistication, new challenges and considerations have emerged. This presentation will cover the fundamentals of high parameter flow cytometry (HPFC), highlight similarities and differences between conventional and spectral flow cytometry, and discuss considerations for assay workflow, from panel optimization to standardization of data analysis and reporting, to produce high-quality data.
Learning Objectives:
Upon completion, participants will be able to understand the differences between conventional and spectral flow cytometry.
Upon completion, participants will be able to identify key considerations for panel design, sample analysis, and data reporting, as well as understand challenges within the workflow and data interpretation.
Upon completion, participants will be able to appreciate the advantages of using high parameter flow cytometry in clinical trials as well as recognize opportunities for its application.