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The TIM Company is a CRO based in the Netherlands, utilizing its novel in vitro technology to predict oral formulation behavior in vivo. As the most advanced intestinal models which simulate all physiologically relevant conditions (pH, gastric motility, peristalsis, gastric emptying & more), we are able to simulate healthy adults, disease conditions, fasted/fed states, and PPI conditions to support:
Development and optimization of formulations,
Risk assessments related to bridging between formulations used in different stages of the clinical trial programs or commercial manufacturing.
Selection processes between different drug substance modifications, that is, different salts or solid forms, and/or formulations.
Predicting food interactions.
Predicting dose linearity in exposure because of solubility limitations
With expertise built over 30 years, and trusted relationships with industry, TIM Studies represent a unique asset in your the development process. From formulation ranking, to food-effect, to microbiome studies, we’ll design your TIM study to provide valuable insights into your formulation performance & accelerate your drug development timelines.